The
research in our laboratory is focussed on the cellular and molecular mechanisms
involved in neurite elongation in central neurons. Neurite elongation
and the differentiation of axons and dendrites are the result
of the interaction of external cues and intracellular mechanisms. Extracellular
cues that could modulate the direction and extent of neurite growth include
components of the extracellular matrix, cell adhesion molecules and soluble
factors such as agrin. Intracellular mechanisms provide structural elements,
microtubules and actin filaments, to support and maintain elongating neuronal
projections. Currently, we are analyzing the role of agrin in neurite elongation
and synapse formation in cultured hippocampal neurons.
We are also interested
in studying the cellular and molecular mechanisms involved in neurite
degeneration associated with Alzheimer's disease. Our
studies focus on the relationship between senile plaques and neurofibrillary
tangles, the two hallmark lesions in Alzheimer's Disease. Currently, we are
analyzing the role of tau in Ab-induced neurite
degeneration.
